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Key strengths of this study were the inclusion of multiple burden measures, and the use of population-level datasets, to provide a comprehensive overview of the impact of regionalization of trauma care on injury burden in a defined trauma setting.
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It is expected that investigators will almost certainly use multiple, more detailed, and potentially higher burden measures to assess their primary research interest but will use PhenX measures to expand their study to include measures from other research domains.
Mental health conditions are common in poverty contexts, especially where caregivers face multiple burdens.
A limited number of higher-burden measures may be included.
Whilst several outcome measures are needed to capture the impact of a disorder like CTS on the individual, the use of multiple outcome measures which address the same domain such as motor function should be avoided as it places an unnecessary burden on the patient and clinician.
Moreover, while we cannot exclude the possibility that adverse effect burden is simply a proxy for medical and psychiatric morbidity, we note that independent effects of this variable persist after adjustment for multiple other measures of comorbidity.
Using multiple measures of HRQOL can help to assess the burden of poor health in a population, identify subgroups with unmet HRQOL needs, inform the development of targeted interventions, and monitor changes in a population's HRQOL over time.
To measure power of each method while correctly accounting for the multiple testing burden of each method, we perform the following simulation procedure.
The association of greater smoking chronicity and poorer performance on multiple measures after control for alcohol consumption suggests that chronic smoking adds an additional burden to neurocognitive function in those with alcohol dependence.
"There's need for multiple measures".
Multiple headache symptom measures were evaluated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com