Sentence examples for multiple breakpoints in from inspiring English sources

Among the many advantages of high-throughput NGS, SVs of all types and sizes can theoretically be detected, breakpoints can be mapped with high resolution, down to the basepair level in some instances, and complex rearrangements can be characterised with the possibility to study multiple breakpoints in a single experiment.

We observed that multiple breakpoints existed in high level amplification regions involving 11q13.3 were located in 67-72 Mb position in three ESCC cell lines we detected and ten online cell lines, which is similar to the amplification peak in HNSCC [ 75].

Multiple breakpoints are present in most of the cell lines, revealing these positions may be highly rearranged.

Concerning the presentation of multiple breakpoint boundaries in some of ESCC cell lines and primary tumors with high-level amplification of 11q13, several cycles of random breakages may be undergone.

In one patient, MYC was translocated with multiple breakpoints suggestive of convergent evolution of independent rearrangement events in different subclones (Fig. 1b).

It is likely that there are multiple breakpoints of CNV regions within the areas of homology in this locus.

Many of the sequences contained multiple breakpoints so that the number of breakpoints on each graph is typically larger than the number of recombinant sequences listed in Tables 1 7.

Both dementia patients contained numerous intra-tissue recombinants with many sequences containing multiple breakpoints along gp120.

We show that YAHA detects more breakpoints in less time than BWA-SW across all SV classes, and especially excels at complex SVs comprising multiple breakpoints.

We chose to stick with the above-described evaluation (where such breakpoints are called false positives) in order not to favor methods such as the (group) fused lasso that tend to systematically find multiple breakpoints very close to each other, which is generally inconsistent with the biology of cancers.

Murphy et al. [ 40] have shown multiple breakpoints within the ancestral chromosome 1 among different mammalian orders, whereas HSA 5 has been shown to be conserved in xenarthrans but was involved in different rearrangements across distant mammalian lineages.