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To investigate the targeting accuracy of intensity-modulated SRS (IMRS) plans designed to simultaneously treat multiple brain metastases with a single isocenter.
To define the maximum tolerated dose (MTD) of a SHort-course Accelerated whole brain RadiatiON therapy (SHARON) in the treatment of patients with multiple brain metastases.
In patients with multiple brain metastases who experience important neurological symptoms, palliative treatment, with or without whole brain radiation therapy (WBRT), needs to be considered the first step of a multidisciplinary therapeutic approach.
Brain magnetic resonance imaging (MRI) revealed multiple brain metastases.
As underlying causes they found 4 patients with an obstructive hydrocephalus, two patients with a Chiari malformation type I, one patient with a subdural hematoma, one with multiple brain metastases and one with an acute sphenoid sinusitis [3].
Eighty-eight per cent of respondents chose comfort measures only for patients with multiple brain metastases who have been previously treated with WBRT and who now present 6 months later with two to four brain metastases (all less than 4 cm in size) with uncontrolled extracranial disease and bedridden state.
Similar(25)
Aims: Trials have shown that patients with multiple-brain metastases and poor prognostic features have a short median survival after whole-brain radiotherapy (WBRT).
3. A 58 year old woman with known lung cancer develops multiple supratentorial brain metastases.
A CT scan of the head revealed multiple bilateral brain metastases (prior CT's of the head negative, within six months), predominantly in her frontal lobes with possible interventricular extension.
Each stage of tumor metastasis involves mechanisms that might function in a sexually dimorphic fashion and thereby contribute to the disparate rates of brain metastases observed in multiple cancers.
Favourable independent prognostic factors were: normal pre-treatment level of serum lactate dehydrogenase (P<0.001), administered therapy (neurosurgery or SRS vs other, P=0.002), number of brain metastases (single vs multiple, P=0.032) and presence of bone metastasis (false vs true, P=0.044).
More suggestions(15)
multiple brain sections
multiple brain tissues
multiple brain circuits
multiple peritoneal metastases
multiple brain regions
multiple brain infarctions
multiple brain abscesses
multiple brain centers
multiple brain networks
multiple brain surgeries
multiple tumor metastases
multiple bone metastases
multiple brain IPCs
multiple organ metastases
multiple brain processes
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com