Leveraging the knowledge from studies of different behaviors mediated by nicotine receptors in multiple brain circuits could provide points of convergence that will inform future therapeutic development for smoking cessation.
Arousal regulation involves multiple brain circuits such as the Default mode network, emotional network and executive control network.
Based upon these studies, we hypothesize that the effects of varenicline on ethanol consumption result from activation and desensitization of nAChRs in multiple brain circuits.
Because loss of GABAergic neurons is the most prominent phenotype arising from this mis-specification, ZC4H2 loss of function may therefore result in hyperexcitability of multiple brain and spinal circuits.
Interesting brain-genome associations can be identified at multiple levels (Fig. 4): In the genomic domain, we can examine candidate genes/SNPs, relevant biological pathways/networks, or the entire genome; similarly, in the neuroimaging domain, we can study an individual region of interest (ROI), interesting brain circuits including multiple ROIs, or the whole brain.
In this study, our goal is to identify high-level associations between gene sets and brain circuits, which typically include multiple genes and multiple QTs.
These findings suggest that an IA memory is enhanced/reconsolidated through the reactivation of memory circuits consisting of multiple brain regions including the amygdala, hippocampus, and mPFC and that the amygdala plays central and distinct roles from the hippocampus and mPFC in the enhancement/reconsolidation of IA memory.
Our ultimate goal is to discover high-level associations between meaningful gene sets (GS) and brain circuits (BC), which typically include multiple genes and multiple QTs.
Indeed, the body schema cannot be localised to a single brain area, but arises from the dynamic exchange of information within a network containing multiple brain areas, including the posterior parietal, premotor, and primary sensorimotor cortices as well as other subcortial and spinal circuits [59], [60].
The scanner lets us examine how their brain circuits differ.
Children internalize those reactions in emotional brain circuits, he said.
