After treatment, there was a decrease in the FDG uptake intensity in multiple bone metastases in the thoracic and lumbar spine, with the exception of 1 lesion in L3, suggesting a degree of within-patient response heterogeneity.
Systemic evaluation including positron emission tomography - CT, bone scan, and magnetic resonance (MR) images revealed distant metastases in both the lungs and in multiple bones.
Emission CT (ECT) was performed in five cases and showed significantly increased uptake in multiple bones.
A lacy pattern with small osteolytic areas is recognizable in the digits (white arrows in Fig. 16a and b) Open image in new window Fig. 17 Multiple bone lesions in a 51 year-old man.
It is now recognised that FD can occur as a solitary focus (monostotic form), in multiple bones (polyostotic form), or as part of the McCune Albright syndrome.
The monostotic form of FD is limited to one bone, whereas the polyostotic form is manifest in multiple bones [ 2].
Positron emission tomography/CT (PET/CT) was performed in two cases and showed diffuse lymphadenopathy, whole-body bone metabolic activity, and destruction in multiple bones.
However, she additionally developed left hydronephrosis and multiple bone metastases in the skull, right acetabulum, and right iliac crest 5 months after the therapy was changed (Fig. 1e).
Radiography, computed tomography and magnetic resonance imaging revealed multiple bone infarcts in both femurs.
Without confirmation in additional cohorts of mice, phenotypes identified in HTS can represent false positive findings due to the necessity of examining multiple bone parameters in a small number of mice.
