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In contrast, hTNFtg mice not only developed intense inflammation but also showed multiple bone erosions.
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In those patients there is multiple chronic osteomyelitis, and bone erosions are intraosseous and not periarticular as seen in our murine model or in patients affected by RA.
Bone erosions: 0 = normal; 1 = mild (focal subchondral erosion); 2 = moderate (multiple subchondral erosions); 3 = high (as above + focal erosion of talus); and 4 = maximum (multiple erosions of tarsal and metatarsal bones).
Multiple bone islands are noted.
The presence of bone erosions is a sign of structural joint damage and the presence of BMO may be predictive of later bone erosions [27, 28].
Bone erosions were scored from 0 to 4 as follows: 0 = normal; 1 = mild (focal subchondral erosion); 2 = moderate (multiple subchondral erosions); 3 = high (as above + focal erosion of talus); and 4 = maximum (multiple erosions of tarsal and metatarsal bones).
No bone erosions were present on radiography.
We then assessed bone defects and bone erosions on MRI.
Bone erosions were assessed with a semiquantitative score as follows: grade 0 = no erosion, grade 1 = 1 erosion, grade 2 = 2 erosions, grade 3 ≥ 3 erosions.
Bone erosions were an isolated finding 17.1% of the time.
No leukocyte infiltration or bone erosions were observed.
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