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There are subtle differences between the III and multiple bolus dosing of drugs in terms of estimation of some pharmacokinetic parameters such as maximum plasma concentration (Cmax) and volume of distribution (V).
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On the contrary, the patients of the control group required high doses of nalbuphine given as continuous intravenous infusion intraoperatively, and in multiple bolus doses postoperatively.
In addition, the newest insulin pumps account for residual insulin action in their bolus calculator software to prevent hypoglycemia related to multiple bolus doses given over a short interval.
bfirst-day PK; cPK after bolus dosing; dPK after 1-g bolus dosing; efor 70 kg; fcentral compartment; gPK after 500-mg bolus dosing.
We administered haloperidol by infusion rather than conventional bolus dosing.
48 Continuous infusion showed no advantage over bolus dosing.
Analgesic component maintained by paravertebral analgesia and phentanyl bolus dosing.
Patients used the optional bolus dosing feature on the e-diary to generate an adjusted bolus insulin dose 171,148 times (Table 3).
Patients also used the form to document meals, physical exercise, basal insulin doses, prandial bolus doses, and correction bolus doses over the 3-day testing period.
TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple bolus or dietary dosing using known PK information.
The session is scheduled around the middle of the semester after coverage of the pharmacokinetics of single oral and intravenous doses, constant intravenous infusion, and multiple bolus intravenous or oral doses.
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