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The multiple blood sampling that is necessary in pharmacokinetic and toxicokinetic studies are possible, as well as multiparametric monitoring and interventions with equipment used in human clinical settings.
Invasive procedures such as multiple blood sampling and bone marrow sampling are also performed.
For these reasons new prospectively controlled and randomized trials with multiple blood sampling must be performed to confirm our results.
This procedure for multiple blood sampling does not cause any adverse effects (8, 9, 23, 25, 36, 37).
Multiple blood sampling requires additional staff and may be more difficult in the clinical setting or in large-scale studies.
Alternatives to multiple blood sampling exist, including general population standard curves [ 17] or reduction of the number of blood samples [ 4, 8].
Similar(50)
One of the limitations of this study was the inability to collect multiple blood samples for the analysis of C peptide within the two hour sampling period, hence the need to use a simplified method for estimation of beta cell responsiveness.
In addition, as part of the fenfluramine test, the children had to fast for 18 hours and had a catheter placed in a vein from which multiple blood samples were drawn over several hours, a procedure that left some feeling nauseous and headachy.
The swine coronary circulation mimics the human circulation and is large enough to obtain multiple blood samples in survival experiments.
In addition, pigs allow for multiple blood samples as well as dosimetry assessment during a long period.
We performed this study to measure the changes in hematocrit (Hct) during a laboratory investigation where multiple blood samples are collected.
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