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She established the first clinics specifically for twins - in London, Birmingham and York - wrote five sets of guidelines on multiple births for professionals and became an associate editor of Twin Research.
To explore this further we have examined data on the mean frequency of single and multiple births for carriers of the Inverdale mutation (FecXI) and for wildtype Romney sheep [18].
We computed preterm birth rates for all births and for singleton and multiple births for each time point.
Adjustment till be made for clustering due to multiple births for infant outcomes using generalized estimating equations.
Adjustment will be made for clustering due to multiple births for infant outcomes using generalised estimating equations.
If the mother was the focus of the analysis, only one data set was analyzed in multiple births, for instance, in relation to diseases and prenatal parameters.
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The methods compared were 1) assuming independence among infants, 2) analyzing outcomes per mother, 3) randomly selecting one infant from each multiple birth for inclusion in the analysis, and 4) cluster trial methods.
Some categories increased even more: specifically preterm birth < 32 weeks increased 32.3% for singletons and 50.6% for multiple births (p for trend 0.0001).
Total preterm births rose from 5.0%to6.6%6%, with increases of 28% for the singletons and 31% for multiple births (p for trend < 0.0001).
The current study found increased rates of PTB for older women having first births as well as subsequent births, for singleton but not multiple births, and for those who did not use ART but not for those who did use it.
This increase is significant among multiple births (p for trend < 0.0001) but not among singletons (p for trend = 0.06).
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