Such cLBP is often termed nonspecific and may be due to multiple biologic and behavioral etiologies.
Subject 3 had the most number of previous treatments including multiple systemic treatments and multiple biologic therapies.
The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer.
Upon activation, JNK induces multiple biologic events through the transcription factor activator protein-1 and transcription-independent control of effector molecules.
Highly specific binding of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) by vitamin D receptor (VDR), a nuclear transcriptional factor, activates a genomic mechanism that is manifested in the multiple biologic properties of 1α,25(OH)2D3.
Activated Rho GTPases bind to and activate several downstream effectors, leading to multiple biologic processes, such as cellular size, cell cycle progression, apoptosis, survival, morphology, cellular polarity, cellular adhesion, and membrane trafficking [20], [21].
Cilia, like other organelles, are constantly broken down and regenerated, and it is likely that cigarette smoke, with its many toxic components, affects multiple biologic processes involved in cilia growth.
IL-18 – functionally related to IL-1 – is a proinflammatory cytokine with multiple biologic functions [ 40].
Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression.
Our data show the multiple biologic systems that respond to the transfection reagent, especially inflammatory and immune related pathways.
