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Corresponding to the complexity of the components in diverse herbs or even in one herb, herbal medicines hit multiple biological targets involved in various pathogenesis.
Small molecules that act on multiple biological targets have been proposed to combat the drug resistance commonly observed for cancer chemotherapy.
Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology.
Promiscuous compounds specifically interact with multiple biological targets.
Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets.
In fact, the design of single agents that act against multiple biological targets is of increasing interest and prominence.
Similar(52)
Multiple biological CBX4 targets have been identified which begin to link PcG-mediated sumoylation to relevant biological processes [ 32, 34- 38].
The hydrophobic property of the fluorinated chain imparts the proteinophilic and lipophilic property of PFCs and results in the interaction of PFCs with multiple biological molecular targets in various species.
The application of "protective", low volume mechanical ventilation often leads to an increase of arterial CO2 levels which - if not corrected by the physician - is called permissive hypercapnia and has been shown to affect multiple biological system targets.
It has been recognised that IBP and the other 2-arylpropanoic acids have multiple human biological targets, as demonstrated by their numerous therapeutic applications, acting as analgesics and anti-inflammatories but also for treating neurodegenerative diseases and cancer.
Currently, the majority of drug candidates are aimed at cancer treatment and are therefore studied for activity at multiple, possibly novel biological targets, presenting a high probability of multiple unique toxicological profiles [3].
More suggestions(15)
several biological targets
multiple biological pathways
multiple biological outputs
multiple biological tools
multiple biological redundancies
multiple biological scales
multiple biological functions
multiple biological settings
multiple biological disciplines
multiple biological samples
multiple subcellular targets
multiple biological factors
multiple biological mechanisms
multiple biological reasons
multiple biological roles
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