As the reviewer points out, P450s tend to be broad range, and catalyze multiple reactions in biological settings.
In order to understand the effects of autophagy in a given biological settings, it is absolutely necessary to carry out multiple assays and compare the results of these investigations as a whole.
Here we report that Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in multiple biological functions that has already acquired diagnostic relevance in specific clinical settings, is variably expressed in most differentiated and less aggressive neuroblastic tumors, such as GN and ganglioneuroblastoma, as well as in a subset of NB cases.
Multiple biological activities of APC have been demonstrated both in clinical and experimental settings, comprising pro-fibrinolytic, immune-modulating and anti-apoptotic properties [ 15- 21].
Our assumption is that, because high-ranking cliques consist of the TFs deemed to function cooperatively in multiple instances by our algorithm, they may truly function as partners in real biological settings.
This might be particularly important for functional dissection of BMP signaling in complex biological settings like in vitro ES cell differentiation, where BMP signals are required at multiple time points to regulate a number of diverse developmental events [10], [12], [14] [16].
The numerous possible roles of TNF in autoimmunity are somewhat difficult to define not only by virtue of the multiple biological effects of TNF, but also due to different effects in different models and under different settings.
Occurring in a multitude of biological settings, from an artichoke to a snail shell, the Fibonacci sequence articulates, as Uglow puts it, "the geometry of life".
Niclosamide has multiple biological activities.
Multiple biological factors might participate in REL2 controlled leaf rolling.
