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Our analyses of the global responses to chronic stressor exposure, at multiple biological levels, revealed a viable neural phenotype in-part reminiscent of aged or damaged neural tissue.
In this manuscript, we consider not only microarray data but also high-throughput data from multiple biological levels.
A mosaic of contingent and deterministic processes at multiple biological levels may be a general property of the evolution of novelty.
Introducing a disease AOP concept, analogous to toxicity AOPs, with the intention of providing a unified framework for describing relevant pathophysiology pathways and networks across multiple biological levels.
Maus et al. [ 10] have addressed a growing need for modeling tools that span multiple biological levels of organization by developing a multi-level rule-based language, called ML-Rules.
Human disease should be conceived as resulting from integrated extrinsic and intrinsic causes, with research focused on modern human-specific models to understand disease pathways at multiple biological levels that are analogous to adverse outcome pathways in toxicology.
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Together these data suggest that the trajectory of our RWs, despite wide variation in scale, are relevant at multiple nested biological levels, including between sexes, between species, and across the Lake Malawi radiation as a whole.
Responses to such multiple stressor effects on different biological levels and temporal scales are not considered in current risk assessment practices.
Moreover, given the pleiotropic effects caused by the mutational inactivation of VosA and VeA [15] [18], these regulators may act globally at a higher hierarchic level influencing multiple biological processes.
However further manual curation is required by the community using RNA-seq supporting evidence from multiple biological situations to achieve the high level of novel transcriptome information needed to complete this important activity.
It has been established beyond doubt that the general population in a heavily industrialized region such as Flanders has an internal exposure to heavy metals and genotoxic or receptor binding pollutants at a level associated with multiple biological and health effects [ 20, 21, 51- 53].
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multiple biological scales
multiple biological tiers
multiple genetic levels
multiple biological pathways
multiple biological modules
multiple biological redundancies
multiple biological functions
multiple biological processes
multiple biological replicates
multiple biological targets
multiple biological fluids
multiple biological consequences
multiple biological samples
multiple biological factors
multiple biological barriers
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