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What has become clear from the growing list of BIPs is that BRCA1 is probably involved in multiple biologic programs of cellular behavior, including transcription, cell-cycle regulation, DNA damage repair, centrosome duplication, and cell growth and apoptosis.
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Subject 3 had the most number of previous treatments including multiple systemic treatments and multiple biologic therapies.
Such cLBP is often termed nonspecific and may be due to multiple biologic and behavioral etiologies.
The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer.
Upon activation, JNK induces multiple biologic events through the transcription factor activator protein-1 and transcription-independent control of effector molecules.
IL-18 – functionally related to IL-1 – is a proinflammatory cytokine with multiple biologic functions [ 40].
Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression.
We defined NOVA CLIP tag clusters by grouping overlapping RNA tags identified in multiple biologic replicates (biologic complexity (BC) > 2) (Licatalosi et al., 2008) from four independent animals.
Our data show the multiple biologic systems that respond to the transfection reagent, especially inflammatory and immune related pathways.
Our analysis included more than 300 molecules representing multiple biologic pathways believed to be important in the pathogenesis of AKI.
However, it is likely that the multiple biologic activities of this agent were critical to its success in PROWESS.
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