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The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer.
Activated Rho GTPases bind to and activate several downstream effectors, leading to multiple biologic processes, such as cellular size, cell cycle progression, apoptosis, survival, morphology, cellular polarity, cellular adhesion, and membrane trafficking [20], [21].
Cilia, like other organelles, are constantly broken down and regenerated, and it is likely that cigarette smoke, with its many toxic components, affects multiple biologic processes involved in cilia growth.
Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression.
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Arginine is a non-essential amino acid processed metabolically by the urea cycle and involved in multiple metabolic and biologic processes including release of several hormones, immune response, the regulation of inflammation, collagen synthesis during wound healing, and tumor biology [ 4].
NF-κB is an important transcription factor that mediates expression of multiple genes in important biologic processes including cell growth, apoptosis, and transformation [ 30- 32].
Many fundamental biologic processes (e.g., branching morphogenesis) and associated signaling events involved in development of multiple organs are highly conserved.
Because the same biologic processes "clear" medications and environmental toxicants, there is concern that older adults who take multiple medications may be at increased risk of adverse reactions between medications and concurrent or subsequent environmental exposures.
A biologic medical product (biological or biologic) is a medicinal product that is produced by biologic processes rather than chemical synthesis.
Besides shortening of signal transduction pathways, mutations may also induce rewiring of signal transduction pathways (Pawson and Warner, 2007) and remodelling of key biologic processes including alterations of the protein protein, protein DNA and RNA DNA interactome with similar putative effects on multiple pathways and processes.
As scientists, we are not able to measure dynamic biologic processes in real time; instead, we must rely on static measurements made at a single or multiple time points.
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