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Our analysis included more than 300 molecules representing multiple biologic pathways believed to be important in the pathogenesis of AKI.
The gene encoding the cytokine IL-13, similar to another ontology member, namely cytokine IL-1ß, described above, is involved in multiple biologic pathways (Table 1).
Combination specific PAH therapy in CTD-PAH targets more than one of the multiple biologic pathways involved in disease pathogenesis [ 2].
Among the multiple biologic pathways in which NHERF1 is involved, the signaling event that is most relevant to NHERF1 pathobiology in mammary gland is not known, nor is it certain that NHERF1 elicits tumour suppressor activity in breast.
Proteomic data sets with large and complex arrays of candidate markers mapping across multiple biologic pathways present limits to the interpretation of univariate data by disregarding potential protein-protein interactions as a basis for accurate disease profiling.
Proteins with changed concentrations contributed to multiple biologic pathways relevant to the observed clinical effects of HT, including coagulation, inflammation, immune response, metabolism, cell adhesion, growth factors, and osteogenesis.
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Toxicogenomics provides an opportunity to move beyond traditional approaches to exposure assessment based on one chemical agent in one environmental medium (air, water, soil) at a time, to a more realistic view of exposure involving multiple exposures, at potentially low environmental concentrations, and multiple biologic response pathways.
IL-6 is differentiation factor cytokine with activity toward a wide variety of biologic systems [ 15- 17] and IL-1ß is involved regulating multiple biological pathways, including inflammatory and immune responses and immune cell differentiation [ 18].
In the present study, we have evaluated biologic pathways altered among multiple SAID by studying levels of plasma proteins using LC-ESI-MS from MZ twins discordant for SAID and unrelated, matched controls.
The final functional outcome of this cascade of intracellular events is the induction of the multiple biologic effects of the PI3K/AKT/mTOR signaling pathway.
IFN- α can elicit multiple biologic functions because of its diverse signaling pathways, including Rap1, CrkL, VAV, MAP kinase, and PI3-kinase [ 13– 15].
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multiple biologic functions
multiple biologic programs
multiple biologic therapies
multiple biologic processes
multiple biologic data
multiple biologic markers
multiple biologic properties
multiple biologic systems
multiple signaling pathways
multiple biologic factors
multiple biologic activities
multiple biologic effects
multiple biologic events
multiple biochemical pathways
multiple genetic pathways
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