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IL-18 – functionally related to IL-1 – is a proinflammatory cytokine with multiple biologic functions [ 40].
IFN- α can elicit multiple biologic functions because of its diverse signaling pathways, including Rap1, CrkL, VAV, MAP kinase, and PI3-kinase [ 13– 15].
IRFs, a family of nine mammalian transcription factors, have multiple biologic functions that when dysregulated may contribute to tumorigenesis; most well-known are their roles in regulating/initiating host immunity.
Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biologic functions such as transcriptional and translational control.
Syntenin is a scaffolding-PDZ domain-containing protein involved in multiple biologic functions, including syndecan binding and recycling, receptor clustering, protein trafficking, signal transduction, and regulation of the transcription factor Sox4 proteasomal degradation [ 2- 7].
Basic science studies find multiple biologic functions for BRCA1 and BRCA2 proteins [ 6- 15], including participating within a pathway that mediates error-free repair of DNA double strand breaks by homologous recombination [ 15].
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In this regard, although the biological importance of SAA in USPC patients is not well understood, previous reports have suggested multiple important biologic functions of SAA.
Estrogen plays multiple biological functions.
The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer.
In vivo, lymphocytes often receive multiple stimuli and become activated to carry out their biologic functions.
All the distinct gene identification were examined for their known biologic functions according to gene oncology convention and grouped in the respective functional category.
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multiple biologic replicates
multiple biologic programs
multiple biologic therapies
multiple biologic processes
multiple biologic data
multiple biologic properties
multiple biologic markers
multiple biologic systems
multiple biologic factors
multiple biologic activities
multiple biologic effects
multiple biologic pathways
multiple biologic events
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