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More recently, integrative screening combining genome-wide RNAi screens with multiple biologic data have been developed to filter for high-confidence candidate targets [ 12].
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Our data show the multiple biologic systems that respond to the transfection reagent, especially inflammatory and immune related pathways.
Proteomic data sets with large and complex arrays of candidate markers mapping across multiple biologic pathways present limits to the interpretation of univariate data by disregarding potential protein-protein interactions as a basis for accurate disease profiling.
This study has an important implication in CER of RA and shows the potential for using the claims data to compare the clinical effectiveness of multiple biologic or non-biologic DMARDs in large real-world populations.
ANOVA for clinical and biologic data were performed to test the differences among groups, and the Bonferroni post hoc test for multiple comparisons was further performed.
Considering normally distributed data, ANOVA for clinical and biologic data was performed to test the differences among groups, and the Bonferroni post-hoc test for multiple comparisons was further performed as requested.
Biologic data reinforce these observations [9].
Demographic, biologic data and concomitant drugs were collected.
Subject 3 had the most number of previous treatments including multiple systemic treatments and multiple biologic therapies.
Such cLBP is often termed nonspecific and may be due to multiple biologic and behavioral etiologies.
The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer.
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