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The tendency of short protein fragments to align to their structural homologs is a confounding factor in functional annotation due to the multiplicity of functions of homologous protein domains (same domain may perform multiple biochemical functions).
Our finding of a distinct role for the SBD in cell migration is consistent with the multiple biochemical functions attributed to this domain [16], [27], [28].
Transglutaminase 2 (TG2), a protein crosslinking enzyme with multiple biochemical functions, has been connected to various inflammatory processes.
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These include the recruitment of multiple enzymes into new biochemical functions, massive shifts in the spatial distribution of proteins and organelles, and a set of anatomical modifications to cell size and structure.
These multiple and very different biochemical functions make it clear that the plastid outer envelope membrane is not a more or less "static" remnant of the endosymbiotic process, but an active player in the biochemical and genetic network of the plant cell.
Following stress, p53 is phosphorylated at multiple residues, thereby modifying its biochemical functions required for increased activity as a transcription factor.
More often than not, cellulase-encoding genes appear as multiple copies in the genome of sequenced microorganisms and enzymes occur as functionally redundant with overlapping biochemical functions.
In the present study, we have employed multiple biochemical methods to better understand the structure-function relationship of AVR proteins focusing on AVR2.
In the human body, it is critical for multiple biochemical processes, as it plays a fundamental role in the structure and function of a number of metalloenzymes.
Some plant ABC transporters have been identified in multiple genetic screens and have been ascribed several different biochemical functions, based on their apparently disparate physiological roles.
Correlative SAR can establish new relationships between specific biochemical functions and higher-level cellular processes, particularly for proteins with multiple functions and small molecules with unknown or various modes of action.
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