Exact(4)
Polymer-based, injectable systems that can simultaneously deliver multiple bioactive agents in a controlled manner could significantly enhance the efficacy of next generation therapeutics.
Bioengineering smart systems that can simultaneously deliver multiple bioactive agents in a controlled manner or can work as a niche for in situ priming and modulation of the immune system could significantly enhance the efficacy of next-generation immunotherapeutics.
Future combination devices might best be completely re-designed de novo to deliver multiple bioactive agents over several spatial and temporal scales to enhance prosthetic device function, instead of the current 'add-on' approach to existing implant device designs never originally intending to function in tandem with drug delivery systems.
Consequently, such a thermosensitive MHg formulation, which enabled the precise control over the dosage and ratio of combination therapeutic agents to obtain the desired therapeutic effect with a single drug administration and reduced side effects, holds great potential for spatiotemporally delivery of multiple bioactive agents for sustained combination therapy.
Similar(56)
In fact, it has been argued that plants may be sources of multiple bioactive compounds that could provide more benefit than single pharmacological agents against chronic diseases, and this may well be beneficical in managing breast cancer.
The limited efficacy of marketed anticancer agents demands the design of novel target-specific hybrid molecules incorporating multiple bioactive pharmacores to combat cancer.
Oximes and oxime ethers have various synthetic applications and exist in multiple bioactive molecules40,41.
In addition, the PINP result strongly indicates that the bioactive agents need to be present in the medium to promote osteogenesis of hMSCS when cultured on 2D substrates.
Bioactive agents such as proteins or nucleic acids are usually too polar to enter cells directly and hence require carriers for cellular delivery44.
We found that multiple bioactive compounds contained in the HLJDD interacted with multiple targets.
From the ctrl samples, it was also demonstrated that, when the bioactive agents were present, a higher cell seeding density resulted in increased ALP activity.
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