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Starting from separated chains with random conformations, we find a rapid formation of structurally heterogeneous, <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0019129.e002.PNG" class= inline-graphic"/> -sheet rich oligomers, emerging from multiple bimolecular association steps and diverse assembly pathways.
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The aggregates were found to grow via multiple and diverse bimolecular association reactions.
At the gelation temperature above the spinodal temperature (T>Ts), the gelation should be virtually independent of phase separation and then the gelation should occur in terms of bimolecular association and pure crystalline nucleation.
At equilibrium, the fraction of the surface that is covered reaches a steady state and this equilibrium surface coverage (θeq SP is given by the Langmuir absorption isotherm, [40] Figure 3 Time course for value of SPR sensorgrams in analysis of interaction that involves bimolecular association and dissociation.
The X-ray structures of cocrystals between 2,2′-dipyridyl-N,N′-dioxide (1) with fumaric acid (2), itaconic acid (3), succinic acid (4), and oxalic acid (5) were solved to determine if concurrent CH···O interactions were capable of orienting the bimolecular association of the two molecules.
We found that oligomer formation and growth proceeded exclusively by bimolecular association reactions, no trimolecular or higher order association reactions were observed.
The linear dependence of the reaction with [NO] combined with small observed second-order rate constants (kobsNO, Fe3+ in Table 1) is indicative of a bimolecular association rate constant for binding to the pentacoordinate complex that is much slower than the rate constants for His binding and dissociation [22].
The individual bimolecular binding events have characteristic binding parameters; KR and KU represent the bimolecular association constants for the SNF/RNA and SNF/U2A′ interactions, respectively.
Kinetic data for the bimolecular association of PSA with antibody M612166 are shown in Figure 4B.
Direct measurement of the bimolecular association of U2A′ and RRMs has not been done previously.
Therefore, the dimerization process can be modeled by a bimolecular association of two separate DNA tile monomers.
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