S1Rs are involved in a large range of basic biological processes and multiple chronic disease states, including neuropathic pain, depression, Alzheimer's disease (AD), and schizophrenia [2 5].
Given the multiple roles of RTKs in coordinating basic biological processes, modulating their activation levels is a means of achieving different cellular responses in normal processes and in pathological conditions.
TR4 may regulate genes important for basic biological processes shared in multiple cell types, while it may play an additional role in regulating cell type specific genes.
Head and neck squamous cell carcinoma, like all cancers, are associated with multiple genetic defects, which have been linked to dysregulation of basic biological processes (Forastiere et al, 2001; Serewko et al, 2002; Wong et al, 2005; Haddad and Shin, 2008; Endo-Munoz et al, 2009).
Evolution is a complex subject that requires knowledge of basic biological concepts and the ability to connect them across multiple scales of time, space, and biological organization.
Most human diseases arise due to complex interactions between multiple genetic variants and environmental risk factors (1); thus, studying diseases could shed light on basic biological mechanisms.
Indeed, the multiple-knockouts analysis is shown to give a description which is both richer and conforms better with basic biological knowledge than the single knockout analysis.
But basic biological mysteries persist.
To suggest otherwise contradicts basic biological truths".
Examines basic biological processes that operate in sediments.
