Combination of the comparative genomic-based regulon reconstruction with other genome context analysis techniques and multiple available experimental datasets define a knowledge-driven approach for reconstruction of TRNs in a set of related bacterial genomes.
We extracted the interaction network, containing both PPI and GI interactions from multiple publicly available datasets from the BioGRID database [61].
Our data demonstrates the utility of using multiple publically available datasets and resources to identify functional candidates.
Finally, we evaluated pathway activation, as indicated by correlation with the pathway signature, as a risk factor for poor prognosis using multiple unrelated, publicly available datasets.
Flynet utilizes JBrowse (http://www.jbrowse.org/), which allows users to select single or multiple factors from the available datasets and to browse them in a dynamic HTML environment that renders data tracks on the client side (Skinner et al., 2009).
In meta-analysis of multiple datasets – whether from publicly available datasets or experiments produced in the same lab – the strategy is usually the same.
The signature is present in numerous publicly available datasets from multiple cancer types from all solid tumor types that we tried, including nonepithelial cancers such as neuroblastoma and Ewing's sarcoma but not in leukemia.
Furthermore, a recent Victorian report examining the health, wellbeing, development, learning and safety of children and young people of refugee backgrounds highlighted a lack of capacity to identify refugee background people and the limitations and inadequacies of available datasets in multiple sectors (for example, maternal and child health, perinatal health and child development) [ 17].
Mixed-methods study involving collection and triangulation of data from multiple sources, including interviews, surveys, ethnographic case studies, board minutes and publicly available datasets.
Similarly, integrating multiple time-series datasets has become increasingly popular with the growing pool of publicly available datasets [ 50].
