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To this end, multiple autoimmune models have been tested in mice that are genetically deficient in LTαβ/LTßR molecules or tested in mice that are treated with LTαβ/LIGHT pathway blocking agents.
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IL-17 has recently been implicated in the pathogenesis of multiple autoimmune diseases, including rheumatoid arthritis (RA) and the mouse model collagen-induced arthritis (CIA).
Moreover, aberrant T cell activation plays a key role in multiple autoimmune and chronic inflammatory diseases, showing the therapeutic potential of WSX1 in other disease models.
Two years ago, Ms. Holloway, who has multiple autoimmune diseases, left her job for health reasons.
Recently, the concept of multiple autoimmune syndrome has been introduced to describe patients with at least three autoimmune diseases.
Autoimmune disorders are known to be more frequent in women and often associated each others, but it is rare to see multiple autoimmune diseases in a single patient.
The concept of multiple autoimmune syndrome (MAS) has been introduced to describe patients with at least three autoimmune diseases [3, 4].
The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a useful but incomplete conceptual framework for understanding the complex array of factors that lead to the loss of immune homeostasis, myelin and axonal injury, and progressive neurological symptoms.
Using the intensive but clinically relevant approach of chronic systemic delivery, IGF-1 suppressed the autoimmune response in multiple mouse models of autoimmune disease (type 1 diabetes and multiple sclerosis).
Multiple murine models indicate a pivotal role of IL-21 in the pathogenesis of autoimmune diseases [ 7- 9].
Pellino1 is a critical mediator of microglia activation and contributes to the onset of the mouse model for multiple sclerosis, autoimmune encephalomyelitis (EAE).
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CEO of Professional Science Editing for Scientists @ prosciediting.com