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Their high surface area provides tunable multiple attachment sites for acquiring appropriate biological and biomechanical properties.
The FCL has a curved geometry, multiple attachment sites, and preferentially aligned collagen fiber bundles on the posterior surface that are innervated with mechanoreceptive nerve endings.
The HUVEC (human umbilical vein endothelial cells) and rSMC (rat smooth muscle cells) demonstrated a flattened morphology with multiple attachment sites on the gelatin and coaxial scaffolds, with an increase in cell spreading seen as mechanical stiffness of the scaffold increased.
Alternatively, there might be multiple attachment sites for the inter-triplet linker running across the wall of the C-tubule.
However, this approach is limited because most antibodies contain amino groups randomly distributed, leading to multiple attachment sites.
The extent of xylosylation of a selected PG molecule, with multiple attachment sites, varies in different cells, suggesting that xylosylation is an incomplete process.
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An important difference between budding yeast chromosomes and fission yeast or mammalian chromosomes is the presence of multiple microtubule attachment sites per kinetochore in the latter versus only one attachment site per kinetochore in budding yeast.
Since fission yeast does have multiple microtubule attachment sites per kinetochore, it would be interesting to generate a deletion mutant of Pic1 (the fission yeast homolog of INCENP and Sli15), which cannot localize to centromeres and study its effect on fidelity of chromosome segregation and cell viability.
A number of genes in plants have been found to contain multiple poly (A) attachment sites yielding different transcripts from a single gene.
Competition for attachment sites, and multiple simultaneous NK attacks on single targets, would increase as the effector NK cells more radically outnumbered target cells, and hence should be more pronounced at higher E T ratios.
The nondendrimer equivalent to a convergent approach would be bottom-up synthesis of oligomer scaffolds to include multiple copies of the ligand of interest or attachment sites within the oligomer backbone.
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