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Finally, our model was developed using multiple assumptions and extrapolations.
5 Challenges for early development of PBPK models usually arise because of insufficient ADME information, which leads to the incorporation of multiple assumptions and calculated parameters.
Current best estimates of the burden of childhood TB are based upon multiple assumptions and the true burden of pediatric TB is unknown.
It is also important for DS systems to enable exploration of multiple assumptions, and incorporation of new information in response to changing circumstances.
Buxton et al.'s time series of estimated public/charitable UK expenditures on medical research in cardiovascular disease was pieced together from a variety of sources and incorporated multiple assumptions and interpolations [ 18].
Whilst complex kinetic models have been developed in an attempt to correct for some of these factors these are based upon multiple assumptions and data acquired at 1.5 not 3T.
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By its nature, impact assessment involves reasoned judgments in the setting of multiple assumptions, uncertainties, and often incomplete baseline data (Veerman et al. 2007).
Estimating mortality due to the etiologies of pneumonia and diarrhea relies on secondary endpoints and multiple assumptions about those endpoints.
The optimal operating points appear closer to European than United States recommendations, but depend on multiple assumptions including false-positive exam resource costs and the value assigned to a year of life saved [ 72].
However, the physical modeling required us to make multiple assumptions about the biomechanics of the tail, and we wanted to avoid simply tweaking parameters to achieve a model that would fit the data.
However, the multiple Gauss-like distribution of the raw copy number signal among cases and controls, which has been recognized in other studies [1], [7], [8] and in our data manipulation, demands a complicated statistical model with multiple assumptions to analyze CNV-association.
More suggestions(15)
several assumptions and
multiple hypotheses and
various assumptions and
multiple changes and
multiple chins and
multiple commandos and
multiple campaigns and
multiple dogs and
multiple layers and
multiple canoes and
multiple calls and
multiple surgeries and
multiple hospitals and
multiple voices and
multiple cameramen and
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