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Use of the MCM tool could be useful for hypothesis generation, and the confirmation in recent literature of multiple associations that we found supports this assertion.
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Here we present evidence that such event engrams exist and are built from multiple overlapping associations that can be encoded independently.
The associations are ranked by the level of novelty and reliability, which are estimated by combining the strengths of multiple known associations that are directly observable from co-occurrence statistics in the literature.
A greater understanding of these observations is essential for genomewide association (GWA) studies, since they have the potential to identify multiple new associations that that will require external validation.
We modeled multiple disease-environment associations that may underlie the prevalence of Acropora growth anomalies (AGA) (n = 304 surveys) and Porites growth anomalies (PGA) (n = 602 surveys) from across the Indo-Pacific.
Asian groups both individual companies and industry associations that represent multiple companies represent the fastest-growing sector of these buyers, says Epstein.
As a primary discovery approach, screening across unabridged test results poses large statistical penalties for multiple tests eroding confidence in associations that fail to achieve genome-wide significance [ 2, 13- 18, 21].
We assessed multiple association studies that link asthma to single nucleotide polymorphisms within these candidate genes.
We were able to use this and the large number of compounds for which we had data to characterize many associations, identifying those likely to arise through multiple testing and contrasting those with associations that appeared more compelling.
We therefore focussed our discussion on those associations that remained after crude adjustment for multiple comparisons.
Finally, we analysed data from 12 autosomal SNPs identified as showing significant variation across geographical regions of the UK. 14 Our interpretation of these results would be that multiple associations to these SNPs is indicative of regional ascertainment bias of case samples given that control samples are known to be collected from across the UK.
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CEO of Professional Science Editing for Scientists @ prosciediting.com