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The actin cytoskeleton is very dynamic and highly regulated by multiple associated proteins in vivo.
At the core of this machinery are five major snRNPs [small nuclear ribonucleoproteins (U1, U2, and U4 U6 snRNPs)], which each contain a single unique snRNA and multiple associated proteins, some of which are unique to a given snRNP and others of which are shared among snRNPs.
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This suggests that FopC functions to stabilize the outer membrane and that its absence leads to outer membrane destabilization and release of multiple membrane-associated proteins such as AcpA.
Desmin directly interacts with multiple IF-associated proteins.
The second mechanism involves osteocyte cytoskeleton components, including focal adhesion protein complex and its multiple actin-associated proteins such as paxillin, vinculin, talin, and zyxin [ 79].
Two variants of an IS3-like transposon were inserted in different hotspot integration sites of the epidemic lineage I and found to bear multiple surface-associated proteins.
Notably, most of the identified proteins appear to have a function in lipid metabolism; however, multiple LD-associated proteins have not been functionally characterized yet and often co-localize with other subcellular organelles.
While further studies are required to determine how Pa ExoS will respond to different tumorigenic states, the ability of ExoS to target and alter the function of multiple tumor-associated proteins provides the diversity needed accommodate tumor heterogeneity.
MicroRNA (miRNA) is short RNA (˜22 nt) that, in association with other associated proteins, inhibits multiple target genes by regulating their mRNA stability and/or translation.
Although multiple signaling pathways and associated proteins are known to regulate autophagy, either positively or negatively, the mTOR pathway is a well-established negative regulator of autophagy, given that mTORC1 inhibits autophagosome formation, whereas mTORC2 represses the expression of some autophagy-related genes and other autophagy regulators.
Glideosome associated proteins with multiple membrane spans (GAPMs) have also been described (Bullen et al., 2009).
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