Sentence examples for multiple apoptotic pathways from inspiring English sources
Mechanistically, these anti-tumor effects were attributed to induction of G1 phase arrest and activation of multiple apoptotic pathways.
In this sense, multi-target drugs capable of triggering multiple apoptotic pathways will be ideal candidates for chemotherapy.
OBJECTIVE: Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER stress).
Taken together, osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress.
In conclusion, although we have not identified yet a causal link between the different apoptotic pathways and the target molecules of osajin remain unknown, our results indicate that osajin triggers apoptosis of human NPC cells through multiple apoptotic pathways (Figure 8).
Therefore, one altered gene may affect multiple apoptotic pathways.
This finding further suggests that pemetrexed induces multiple apoptotic signaling pathways in cancer cells including the extrinsic apoptotic pathway, and knockdown of intrinsic Noxa and/or Puma cannot sufficiently inhibit apoptosis by pemetrexed in human cancer cells.
As a multitargeted antifolate drug, pemetrexed induces cell cycle arrest by p21 upregulation and multiple apoptotic signaling pathways in human cancer cells including extrinsic death receptor DR5 pathway and intrinsic Bcl-2/Bax pathway as well as the caspase-independent pathway and so on.
Taken together, our data suggest that pemetrexed induces multiple apoptotic signaling pathways, and blocking intrinsic apoptotic proteins such as Puma or/and Noxa cannot thoroughly inhibit the apoptosis.
The antitumor effects of SBL are cancer-selective and are induced through multiple apoptotic signaling pathways that are implicated by mitochondria perturbation and ER stress.
Our study implies that high doses of PL are able to elicit multiple apoptotic signalling pathways in prostate cancer cells, and that caspase 2, acting downstream of the AR, sensitises prostate cancer cells to PL-induced apoptosis.
