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The situation regarding control of tuberculosis has significantly worsened over the last decade with the spread of strains resistant to multiple antimycobacterial agents.
Resolution typically occurred only after an extended course of multiple antimycobacterial agents given simultaneously.
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The results reported here will help global efforts for identification of potential lead antimycobacterial agents.
A series of cinnamide derivatives was designed as potential antimycobacterial agents using molecular hybridization approach.
The camphane-based amides present novel promising scaffolds for antimycobacterial agents.
This is the first report demonstrating the benzofuranone oxindole hybrids as potential antimycobacterial agents.
The majority of tested compounds were efficient antimycobacterial agents showing MIC values ranging from 0.5 to 32 μg/mL.
Further, low cytotoxicity against A549 cell line enhances the potential of the synthesized molecules as promising antimycobacterial agents.
Therefore, these structures can be considered as good starting points for the development of new powerful antimycobacterial agents.
Therefore, quinoxaline derivatives could be considered for making further advances in the future development of antimycobacterial agents.
This has compelled for a global renewal of strategies to search for new or modified antimycobacterial agents effective against drug resistant strains [1, 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com