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The excellent expression, biophysical stability, and potential manufacturing feasibility of these multispecific antibody formats suggest that they will provide a scaffold template for the construction of similar molecules to target multiple antigens in complex diseases.
This is the first study to show enhanced levels of polyclonal IgG4 to multiple antigens in IgG4-RD.
These studies indicate the existence of multiple antigens in Brucella spp. that can elicit protective antibody responses.
The slides were immunofluorescently stained for multiple antigens in sequential manner using Ventana Discovery XT Ventana Medical Systemss) autostainers.
We demonstrated an elevated polyclonal IgG4 response to multiple antigens in patients with IgG4-RD and in PSC-high IgG4, compared with healthy controls.
One of the biggest sources of discussion in the SCIT versus SCIT debate is the clinical use of single antigens versus multiple antigens in immunotherapy prescriptions.
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We found a lower IgG concentration for L-asparaginase as compared to commercial kit 1 (44.8±17.5 versus 148.5±95.5 U/ml) (Fig. 5D) and suspect that this is due to the multiple antigens used in the latter.
Considering that the several existent parasite invasion routes are redundant, the development of the asymptomatic condition will require the recognition of multiple antigens involved in each of these routes.
Second, the whole bacterial vaccine approach relying on multiple antigens and built-in adjuvanticity.
Because responses were examined separately, no multiplicity adjustment for multiple antigens was made in determining the positivity of responses to CMV, CEF or Gag.
Importantly, a response against multiple antigens was seen in the majority of immune responders in both studies.
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