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Typhoid fever, which is caused by the bacterium salmonella typhi, is treated with antibiotics, but resistance to multiple antibiotics is increasing.
A silent epidemic of typhoid that is resistant to multiple antibiotics is spreading across Africa, posing a fresh threat to public health, according to a landmark genetic study of the organism.
Rising infections caused by a type of bacteria resistant to multiple antibiotics is causing longer hospitalizations and may mean a higher risk of death for children in the United States, according to a new study.
For simplicity, we model the acquisition of the DR phenotype as a single-step process, while in reality resistance to multiple antibiotics is caused by sequentially-occurring mutations [10], [11], [12].
The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern.
The resistance to multiple antibiotics is also assumed to be only present in clinical isolates.
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Multiple antibiotics are given to reduce the ability of the bacteria to develop resistance.
Also, combined administrations of multiple antibiotics were more effective to eradicate strains more likely to be internalized.
When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are "exhaustible resources" whose increased use necessarily promotes the rise of resistance.
Staphylococcus aureus strains resistant to multiple antibiotics are increasingly common causes of serious and problematic infections both in hospitals and communities [12], [13].
Kanamycin (50 µg/mL) was used for pre-culturing all of the E. coli BW25113 isogenic mutants, and kanamycin (100 µg/mL), chloramphenicol (30 µg/mL), ampicillin (100 µg/mL), and tetracycline (20 µg/mL) were used to maintain plasmids (for two-plasmid systems, multiple antibiotics were used at the same concentrations).
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