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This type of approach unfortunately leads to greater intraclass variability with less informative conclusions, simply because the windows are artifacts of the analysis and may in fact overlap multiple annotation regions simultaneously.
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The regulatory activity of the candidate regions was visualized through multiple annotation tracks using the University of California, Santa Cruz genome browser (Rosenbloom et al. 2013).
Annotation of the rhesus GeneChip® is under continuous revision with large percentages of probesets under multiple annotation systems having undergone multiple reassignments between March 2007 and November 2008.
These sequences were analyzed through multiple annotation modules, including repetitive sequence annotation, gene prediction, protein function and domain structure annotation.
Unlike many annotation tools, dbWFA makes it possible to query multiple annotation systems simultaneously.
Evidence from multiple annotation tracks suggests a strong regulatory activity.
All three methods weight annotation terms and showed the strongest performance improvement when multiple annotation sources were included.
The remaining analyses were performed on all SNPs, including those with multiple annotations.
All variations were mapped to all transcript models, which led to multiple annotations for several loci.
C scores are based on integration of multiple annotations [ 21].
However, since we test each cluster for multiple annotations, a correction for multiple hypothesis is needed.
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