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Methylation in normal appearing colorectal mucosa from patients with multiple and solitary CRC showed no relevant difference in any evaluated gene.
Comparison of methylation degree between multiple and solitary CRC patients was performed qualitatively where methylation positivity was set as PMR ≥4, as previously validated [23].
Methylation in normal appearing colorectal mucosa from patients with multiple and solitary CRC showed no relevant difference in any evaluated gene (Table 5).
To assess the effect of methylation in tumor multiplicity in sporadic CRC, hypermethylation of key tumor suppressor genes was evaluated in patients with both multiple and solitary tumors, as a proof-of-concept of an underlying epigenetic defect.
Comparison between patients with multiple and solitary tumors regarding the methylation degree in both tumor and normal appearing colorectal mucosa samples was also performed using binomial logistic regression, both unadjusted and adjusted for age and gender.
Regarding the role of methylation in normal appearing colonic mucosa, Konishi et al. recently evaluated the methylation status of several genes (MINT1, MINT2, MINT31, MLH1, p14, p16, MGMT, and ESR1) in the tumor-adjacent normal mucosa from patients with multiple and solitary tumors, and found no significant differences between both groups [31].
Similar(52)
In addition, we demonstrate a copy number increase in HRAS as a "second hit" during the formation of agminated Spitz nevi, which suggests that both multiple Spitz nevi and solitary Spitz nevi may arise through similar molecular pathways.
Abnormalities seen on chest radiographs included lobar (n = 15) or multilobar (n = 6) consolidation, solitary (n = 7) or multiple (n = 1) masses, and solitary (n = 3) or multiple (n = 2) nodules.
MM were multiple in 111 (24.1%) patients and solitary in 350 cases (75.9%).
From September 2011 until March 2013, 80 consecutive patients with a histologically confirmed cancer of any primary and solitary or multiple bone metastases of the thoracic or lumbar segments of the vertebral column or of the os sacrum were screened in the Radiooncology Department of the Heidelberg University Clinic.
The number of solitary, multiple, and diffuse HCC lesions was determined.
More suggestions(15)
multiple and complex
multiple and overlapping
multiple and conflicting
multiple and different
multiple and singular
multiple and pluralised
multiple and divergent
multiple and unforeseen
multiple and severe
multiple and sophisticated
multiple and bilateral
multiple and infinite
multiple and spanned
multiple and interconnected
multiple and varied
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