Moreover, data presented from the studies of cytokines in experimental and natural disease states demonstrate that certain cytokines have the capacity to generate multiple and opposite effects including producing damage, protection, or regeneration.
Because of multiple and opposite influences of the environment on genomic CIN in rho0 cells, as described, one cannot easily predict the outcome of such an experiment (for instance, glucose exhaustion would create a calorie restriction zone and reduce CIN, but production of ethanol would increase CIN).
It is not a single disease, but exhibits a wide spectrum of phenotypic variations involving numerous critical genes and pathways, e.g. TGF-β, NK-κB, TNF-α that may play multiple and even opposite roles [ 2, 3].
Nevertheless, understanding the role of PAR1 signalling in sepsis remains complex due to the multiple and, in part, opposite effects ascribed to this receptor.
Understanding the role of PAR-1 signaling in infection is difficult due to the multiple and in part opposite effects ascribed to this receptor.
Risk factors independently associated with infection are IDU, prior transfusion, prior tattoo, combat medical work, incarceration, and multiple opposite sex partners.
Each of three genera possesses compound female cones that comprise a main axis and 1 to multiple pairs of opposite and decussate bracts or 1 to multiple whorls of ternately arranged bracts which usually subtend a female reproductive unit.
The star topology reflects the presence of a highly or lowly potent compound and multiple analogs having opposite potency, a situation frequently observed in compound optimization.
Meanwhile, the demonstrations against Trump create the exact opposite: a public united along multiple and varied causes, ready and mobilized for action.
The presence of transposons and retroposons in multiple copies in opposite orientations can result in the generation of double-stranded RNA (dsRNA).
Wang K, Baldassano R, Zhang H, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
