Until recently mainly medical CT scanners or micro-CT setups have been used, limiting the analysis to relatively small artworks or requiring multiple acquisition and difficult image-joining for objects larger than detector dimensions.
Even this information, however, is largely incomplete, scattered across multiple sources, and difficult to locate, especially if not catalogued in searchable databases or available in electronic format.
This is especially difficult in oncology, because patients are often treated with drug combinations and because the clinical end points are multiple and sometimes difficult to record.
Their mechanisms are multiple and therefore difficult to bypass.
To do so, software must be developed to simulate multiple and increasingly difficult situations thus to fulfill different pedagogic objectives for diverse universities and training centers.
Mr. Davies's arguments in "The Eerie Silence" are multiple and many-angled, and difficult to summarize here.
The selection of optimal retort temperature profiles with a multistage ramp function involving multiple variables is complex and difficult to handle by conventional optimization methods.
Recent studies have shown that the effects of multiple stressors are often complex and difficult to predict based on the effects of single stressors.
As the breaks are usually multiple, irregular, in thin retina, and difficult to visualize, primary vitrectomy with long-term endotamponade with silicone oil is the preferred modality of management in these detachments [1 4].
Unfortunately, this technology requires multiple, often difficult, bioconjugation steps and it remains ill-adapted to multiplex detection and applications in complex aqueous or biological media.
