It also required that in setting MRLs, the EPA must consider child health, the aggregate risks of exposure to a pesticide in multiple products, and cumulative risks from exposures to multiple pesticides with similar mechanisms of action.
By employing forward stepwise regression analysis, multiple additional (and cumulative) associations between independent variables (LDL, glucose, uric acid, reduced thiols, and bilirubin) and biomarkers of cardiovascular risk (LDL, oxLDL, protein carbonyl) have been identified in this cohort.
In addition to setting tolerance levels for registered chemicals, the FQPA requires the U.S. Environmental Protection Agency to consider aggregate risk from exposure to a pesticide through multiple sources and cumulative risk from exposure to pesticides that have common mechanisms of toxicity.
The multiple, and perhaps cumulative, mechanisms by which resveratrol slows tumour development have been reviewed thoroughly by Baur and Sinclair (2006).
The primary outcomes were live births and multiple live births after the initial fresh embryo transfer, cumulative live births, and cumulative multiple live births (after fresh and frozen embryo transfers accruing from a single oocyte retrieval).
The Supplemental Material (doi 10.1289/ehp.0901675) presents the results for first visits and cumulative and multiple exposures.
The U.S. Environmental Protection Agency EPAA) defines cumulative risk as the combined risks from aggregate exposure to multiple stressors (U.S. EPA 2003), and cumulative risk assessment as an analysis, characterization, and possible quantification of these risks.
Considering both their inherent biologic susceptibility and their long future lifetimes over which early insults can be manifest as chronic disease or cognitive impairment, the fetus and young child can be considered especially vulnerable and at risk of the multiple, cumulative, and long-term health effects of air pollution.
