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So, it uses ISA-Tab handler for scientific workflows that allows the linkage of a single sample to multiple analyses employing various assays [14].
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Attrition rates were low for the study context, and from the results of the analyses employing multiple imputations there was very little bias introduced through missing outcome data.
However, to address the effects of any larger amounts of missing and test robustness of findings, we first completed analyses using simple list-wise deletion, then completed sensitivity analyses employing multiple imputation using chained equations (MICE) for all missing data.
Further analyses employing Dunnett's test for multiple mean comparisons demonstrated that there were no significant differences in mean change from baseline at endpoint for any LDX dose group compared with placebo.
Signal detection analyses employing receiver operator curve (ROC) analysis procedures are well suited to developing dichotomous outcomes from multiple measures (Kraemer, 1992).
The data matrix was subjected to NONA [ 39] analyses, employing a heuristic parsimony analysis, with options set to hold 10000 trees, perform 1000 replications with one starting tree replication, and use of a multiple TBR + TBR search strategy.
Comprehensive sensitivity analyses employed using Monte Carlo simulation to incorporate multiple variables.
Statistical analyses employed the GraphPad Prizm 6.0 program using one-way analysis of variance (ANOVA) for multiple groups and Tukey post hoc analysis.
Analyses employed both per-gene and common variance and utilized the Holm and False Discovery Rate methods to control for multiple testing errors [45], [46].
All analyses employed Statistical Analysis Software SASStatistical Analysis Software SAS
All statistical analyses employed SPSS version 20.
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