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The strengths of our study include a relatively large study population, comprehensive immunological phenotyping comprising different compartments of the immune system, and the availability of additional data on potential confounders so that multiple regression analyses were possible to analyze the impact of metabolic factors or comorbidities on immune activation.
A possible risk of CCO designs lies in "model shopping," whereby multiple analyses are performed using different designs, and only the most interesting are then shown (Mittleman 2005).
No adjustment for multiple analyses was made.
No meta-analyses were possible.
Our analyses suggest that multiple mechanisms are possible, including a decrease in ERK8 protein levels.
Multiple patch systems are possible when multiple pairs are present.
Multiple reasons are possible.
Multiple choices are possible here.
Thus, multiple roles for K3 are possible.
Multiple answers were possible.> Some of the questions used for analyses came from an attached questionnaire utilized by one of the co-authors of this study.
Third, embedding multiple watermarks is possible.
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