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Table 6 summarizes the IMMAD occurrence as part of larger sequences and the prominent co-occurring IMMAD partners.> The present study confirmed the hypothesis that specific sequence elements occur more frequently in introns flanking alternate exons in genes where multiple alternative splicing decisions occur, as compared to genes where only one such decision occurs.
The introns flanking alternate exons in transcripts whose maturation involves multiple alternative splicing decisions were compared to those whose maturation involves a single decision.
The number of possible isoforms can be much higher in genes with Multiple Alternative Splicing decision Sites (MASS), due to the combinatorial arrangement of multiple alternate exons (see an example of MASS gene in Figure 1B).
The variety of tropoelastin isoforms results from multiple alternative splicing of the primary transcript.
In addition, previous study also demonstrated that there are multiple alternative splicing sites in the first half of E2-2 (Setp et al. 2011).
We identified multiple alternative splicing variants for each Cpeb.
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We also considered cases with multiple alternative splice sites, when the number of alternative sites was more than two.
Although multiple alternative splice-forms of WNK1 have been identified, the function of individual transcripts is yet to be determined.
Another analyzed the effects of hypoxia on AS in human umbilical vein endothelial cells (HUVECs) and identified multiple alternative splice events [ 35].
An advantage of MAKER2 is that given sufficient transcript data, it can predict multiple alternative splice forms per locus, while GLEAN computes only one gene model per locus.
As several metazoan H2A.Zs contain a conserved intron directly following the start ATG and possess multiple alternative splice acceptors within their second exon, it will be of interest to determine whether generation of alternative splice H2A.Z variants is not unique to O. dioica.
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