Sentence examples for multiple allosteric regulators from inspiring English sources

In S. cerevisiae, both activities are allosterically inhibited by UTP, while in E. coli there are multiple allosteric regulators.

At the level of molecular biophysics we wish to understand how multiple allosteric inputs regulate channel opening.

Not only is CTPsyn regulated by multimer assembly, end product inhibition and other allosteric regulators as previously discussed, it is also subject to phosphorylation by multiple kinases (Chang et al., 2007; Choi and Carman, 2007; Kassel et al., 2010).

Also, it has been shown that allosteric regulators (inorganic phosphate (Pi) and adenosine monophosphate (AMP)) play a major role in the regulation of glycogenolysis [17].

The presence of multiple allosteric sites in proteins motivates development of allosteric drugs — modulators of protein activity with potentially higher specificity and less toxicity than traditional orthosteric compounds.

However, a limitation of building kinetic models of metabolism (particularly from stoichiometric reconstructions of metabolic networks) is that they often ignore the allosteric regulators.

The present study confirms the existence of multiple allosteric sites on the M1 muscarinic receptor, and lays the ground for further experimental and computational analysis to better understand how muscarinic receptors are modulated via their allosteric sites.

Several PEA3-interacting proteins have been described that function as allosteric regulators and transcriptional coactivators [9], [15], [16].

Ryanodine receptors (RYRs) on the ER have multiple allosteric Ca2+ binding sites responsible for triggering Ca2+- induced Ca2+ release (CICR) into the cytosol [19], [20], [21], [22].

Sac1 is an allosteric enzyme and is predominantly in its inactive form in the absence of allosteric regulators.

These data suggest that multiple allosteric sites exist on mGlu5.