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The collected amino acid sequences of PARP catalytic domains were aligned with MUSCLE3.8.31 multiple alignment tool, using default settings [53].
To facilitate structure-functional analysis of genetic variations in kinase genes, all crystal structures and mutational models were structurally aligned using a java-based multiple alignment tool STRAP (http://www.charite.de/bioinf/strap) and TM-align algorithm [124].
The collected PARP catalytic domains were aligned using the MUSCLE3.8.31 multiple alignment tool, using default settings [ 50].
Full-envelope protein sequences for each serotype were aligned by using the multiple alignment tool of MEGA5 (www.megasoftware.net).net
Sequences were aligned using the MUSCLE multiple alignment tool [ 50, 51] and pairwise differences were calculated using the APE package for the R-project [ 52].
The nucleotide sequences were assembled using the SeqMan II version 5.03 (DNASTAR) and aligned using Clustal W multiple alignment tool in the BioEdit Sequence Alignment Editor version 7.0.9.0 (20 ).
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It is important to strongly adhere to only aligning sequences with significant similarity not including low complexity regions as multiple alignment tools will gladly make alignments with marginal residue identities for any input sequences of similar length and composition.
Because of the jagged start and stop positions and multiple frameshifts and duplications, the standard multiple alignment tools we used failed to give useful alignments of the 454 ultra deep sequence nucleotide data.
Tree construction or progressive multiple alignment tools, in general, are some examples.
Individual fragments were assembled to longer contigs using multiple alignment tools such as ClustalW [ 11] or Multalin [ 12] .
We evaluate the performance of LoQ uM on multiple alignment tools and compare the classifier output with the raw mapping quality (if provided).
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multiple alignment construction
multiple alignment procedure
multiple alignment position
multiple alignment tree
multiple alignment profile
multiple pandanus tool
multiple insert tool
multiple alignment benchmark
multiple alignment method
multiple test tool
multiple alignment generation
multiple alignment analysis
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