Few have assessed these risks separately for each treatment group, i.e. those receiving single or multiple-agent treatment.
If chemotherapy regimens consisted of multiple agents, the treatment arms under comparison could only differ in the presence or absence of an anthracycline or type of anthracycline such that the other therapies being compared were the same between groups.
The surface or core of the nanoparticle may be loaded with multiple agents, so that treatment and imaging of treatment can occur simultaneously.
We also envision the necessity of expanding the dashboard design construct to accommodate multiple agents considered as treatment options for targeted indications.
GDAsBMP produce multiple agents of interest as treatments for PD and other neurodegenerative disorders, including BDNF, GDNF, neurturin and IGF1.
For combinations of agents C i, at effect level E, Equation 1 becomes from which follow equations analogous to Equations 2 and 5 for treatment of multiple agents.
In this paradigm, one begins treatment with multiple agents or agents with broader coverage profiles based on local susceptibility data and then adjusts and/or discontinues anti-infectives as culture and sensitivity (C&S) results return.
Inadequate glycaemic control by OAD treatments including multiple agents would indicate a necessity for insulin administration, often in the form of BOT [ 8].
Modern oncological treatment regimens often incorporate multiple agents whose deleterious effects might be additive or synergistic, making their identification and treatment more challenging.
Multiple agents have shown efficacy in the treatment of bipolar mania including lithium, valproate, and all currently available atypical antipsychotics [ 2- 4].
However, the use of multiple agents contributes to added toxicity, which often results in poor treatment.
