Sentence examples for multiple affected and from inspiring English sources

Pedigree-based linkage studies rely on large "informative" families with multiple affected and unaffected relatives.

She found the linkage by comparing multiple affected and unaffected members in such families.

Furthermore, we were able to study multiple affected and unaffected men in our families, thus strengthening the observation that TM appears to cluster in particular families.

This approach examines families with multiple affected and unaffected relatives, defining a rare genetic variant (pathogenic mutation) that is segregating with the disease.

The VM family dataset was used only for testing the models and consisted of 226 families with multiple affected individuals and their unaffected relatives.

Some syndromic diseases, including Bardet-Biedl syndrome (BBS) and Usher syndrome, exhibit a highly penetrant retinal degeneration phenotype with multiple affected tissues and are also monogenic.

With the present large sample size, we were able to define families with multiple affected individuals and high familial risks.

Autosomal recessive inheritance is less common, but should be considered in consanguineous families or those with multiple affected siblings and asymptomatic parents, or in simplex cases.

Previous studies have distinguished between familial and sporadic forms of schizophrenia by investigating differences between multiplex (i.e., pedigrees with multiple affected individuals) and sporadic (i.e., families with a single affected individual) families.

Nonetheless, for complex diseases like PTC, there may be many genes influencing risk as well as the effects of environment, also, it is much more difficult to collect pedigrees with multiple affected relatives and there is no guarantee of the same (or any) gene (SNP) segregating in these family.

This may be because BRCA1 is a high-penetrance gene and is associated with both early-onset disease and multiple affected family members, and therefore, in the absence of these features, a low prevalence of BRCA1 mutations is found, even in TNBC.