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Although safer than attenuated vaccines, they are generally less effective and require multiple administrations to boost the immune response documented for instance by enhancement of antibody titers over time.
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In particular, adverse side effects due to excess dosage and collateral damage to healthy cells as well as poor patient compliance due to multiple administrations continue to pose challenges in cancer treatment.
Most studies used single administration (68%), 23% used multiple administrations (two to eight times) and 9% of the studies investigated both.
The MTD found in the activity dose-escalation study by Steffens et al. (2220 MBq/m), combined with the properties of cG250 allowing multiple administrations, led to a study where two sequential high doses of [I]cG250 treatment were given.
This information is then averaged over multiple administrations (2 3) to create a table for each individual, summarising the amount of time at each predetermined location for subsequent use in exposure reconstructions.
Multiple administrations allow clinicians to track changes over time to monitor disease progression or to examine responses to changes in treatments.
Consequently, these compounds may need to be given at higher doses or as multiple administrations in order to provide adequate therapeutic concentrations to give an acceptable anthelmintic efficacy [ 3– 5].
Despite its success, this approach again requires multiple nasal administrations to maintain efficacy against EAE.
This article reviews experiments that used multiple administrations of placebo to answer the question "do reliable placebo responders exist?" This paper also examines the evidence for the existence of a consistent placebo responder, i.e. a person who responds to placebo in one situation will respond in another condition or using a different type of placebo ritual.
The public enthusiasm also prevailed across multiple administrations, which turned out to be just long enough to get the job done.
Since 1969, at least eight experiments exposed asthma patients to multiple administrations of placebo given with deceptive suggestions that the "treatment" was an active medication.
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