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This study may provide useful information for a better design of therapeutic regimens involving multiple administrations of nanocarrier drug delivery systems.
Since 1969, at least eight experiments exposed asthma patients to multiple administrations of placebo given with deceptive suggestions that the "treatment" was an active medication.
Other approaches have used reinfusion of "primed" autologous lymphocytes and multiple administrations of GM tumor cells, which required the processing of large amounts of tumor.
"Nothing like this has ever happened at the White House in our long history of covering multiple administrations of different parties," said Dean Baquet, the executive editor of the New York Times.
Lonez, C. et al. Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types.
The Times' executive editor, Dean Baquet, said at the time, "Nothing like this has ever happened at the White House in our long history of covering multiple Administrations of different parties". And that was just the beginning.
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After multiple administration of (A 90Y, (B 111In, (C 177Lu or (D 213Bi to a 300-mg tumour for different tumour doubling times.
Similarly, after multiple administration of edoxaban, 77.0 % of TEAEs were mild and no serious adverse events were reported [ 19].
It is important to investigate whether multiple administration of the therapy will invoke further salutary effects to the infarcted heart.
However, multiple administration of DDP results in the development of drug resistance leading to failure of treatment, as demonstrated by tumor growth or tumor relapse [ 78, 83].
In the arachidonic acid induced ear oedema model in mice, single or multiple administration of an emulsion containing 1.5% was capable of significantly reducing the inflammatory oedema.
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