Multiple administrations of EEA at 300 and 600 mg/kg also significantly increased the frequency and weight of stools, and at 150-600 multipleultiple administrations significantly increased stool water content and the rate of carmine egestion.
EEA at 300 mg/kg showed significant efficacy in normal mice at multiple administrations for 14 days, but was not effective as a single administration.
The biodistribution studies indicate that NPs persist in the intestinal lumen for at least 72 hours after a single administration and are concentrated in the intestine and abdominal lymph nodes after multiple administrations before being completely eliminated at day 7 from the last treatment.
However, multiple administrations of some supposedly valuable compounds at lower concentration may reveal their probability in generating cumulative and latent physiological, biochemical and/or pathological changes [11].
Since 1969, at least eight experiments exposed asthma patients to multiple administrations of placebo given with deceptive suggestions that the "treatment" was an active medication.
"Nothing like this has ever happened at the White House in our long history of covering multiple administrations of different parties," New York Times executive editor, Dean Baquet, said in a statement.
Lindsey C. Kozberg, a spokeswoman at the Education Department, said that some career officials had been in multiple administrations and had been an "outstanding resource".
The mean t1/2,z was 50.1 240.0 h after multiple administrations.
We also examined the cumulative effect of multiple TA administrations at different intervals.
Although multiple administration of time-dependent antimicrobials at standard daily dosage might be useful in clinically stable patients, this may not suffice in patients with glomerular hyperfiltration and/or with infections with borderline susceptible bacterial strains.
