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In a multiple administration study, SS-ILP significantly suppressed the postprandial rise in blood glucose and showed continuous hypoglycaemic effects following 3 times/day oral administration to both diabetic rat groups in the presence of foods.
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The most promising formulation was subsequently used for in vivo multiple oral administration studies using diabetic rats.
The MTD found in the activity dose-escalation study by Steffens et al. (2220 MBq/m), combined with the properties of cG250 allowing multiple administrations, led to a study where two sequential high doses of [I]cG250 treatment were given.
Incensed, multiple administration leaders plotted responses, Clapper said.
Most studies used single administration (68%), 23% used multiple administrations (two to eight times) and 9% of the studies investigated both.
Lonez, C. et al. Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types.
Longer term studies are necessary to evaluate the transduction efficiency following multiple administrations of Sendai vectors.
Although the optimal beneficial cell dose is high, a better approach may be multiple administrations of smaller cell doses, an approach we plan to take for our next study.
This study may provide useful information for a better design of therapeutic regimens involving multiple administrations of nanocarrier drug delivery systems.
The divisions between different directorial administrations were not strict, and in numerous instances files were maintained across multiple administrations.
The mean t1/2,z was 50.1 240.0 h after multiple administrations.
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