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Several strengths of our study also deserve to be mentioned, such as its large sample size, its prospective design, the high retention rate in a long-term follow-up, the multiple adjustments of our estimates for potential confounders, the existence of published validation studies of our methods, and the population of highly educated participants who are able to provide information of high quality.
The two year follow-up will allow for a prospective evaluation of these patients during multiple adjustments of therapy.
Age of the respondent, education, and household socioeconomic status were no longer associated with the likelihood of FGM after multiple adjustments of other factors.
Induction of podoplanin expression results in multiple adjustments of intracellular signalling pathways, leading to the modulation of Rho family GTPase activities, the phosphorylation of ERM proteins, rearrangement of the actin cytoskeleton and, finally, enhanced cell migration and invasion.
Even after multiple adjustments of the urban environment and other risk factors, findings for both women and daughters confirm the fact FGM is lower in the largest urban province Dakar.
Hence, multiple adjustments of these factors have been made for the Odds Ratios (ORs) of health knowledge/experiences for non-RBA groups and RBA groups, together with 95% Confidence Intervals.
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Third, the study is limited in that it is an observational study and, therefore, causality cannot be inferred and because of the relatively low number of patients, multiple adjustments for all comorbidities could not have been performed.
After multiple adjustments, none of the physical conditions were associated with lifetime heavy drinking except for chronic pain, where there was a significant positive association (OR 1.44, 95% CI 1.07-1.93).
Removal of studies rated as lower quality, removal of studies with multiple adjustments, and application of a fixed-effects model (reducing the weighting for smaller studies) weakened the association.
Some items were eliminated quickly, but others required multiple adjustments and rounds of questioning before they were either eliminated or included in the final questionnaire.
The HRs for all-cause and cause-specific mortality by baseline HbA1c category are shown in Table 3. Comparing models 1 and 2, we observed that multiple adjustments strengthen the association of low HbA1c with cause-specific and all-cause mortality, which is consistent with negative confounding.
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