Sentence examples for multiple adjacent genes from inspiring English sources

We showed that the silencing factors exert consistent effects on multiple adjacent genes within a chromosomal domain, unlike Tup1 and Ssn6 (Table S2).

In addition, genomic regions with multiple adjacent genes belonging to the same expression cluster were searched for.

An operon consists of multiple adjacent genes that are transcribed as a single unit, which is then spliced into separate mRNAs for translation.

The operons were classified into Type 1 (orphan), representing single genes with long intergenic distances to neighboring genes, Type 2 (orphan-like), representing single genes with shorter distances to adjacent genes but having defined TSSs and TTSs, and Type 3 (multiple-gene), consisting of transcriptional units composed of multiple adjacent genes.

Univariate linear regression models have been designed to model the associations between individual CN and GE probes [ 26], as well as multiple and/or multivariate linear regression models that combine statistical power across multiple probes targeting adjacent genes or chromosomal positions [ 14, 26 28].

Gene relocations were also supported by the observation that multiple groups of adjacent genes on LS chromosomes showed collinearity with their homologs on the chromosomes of F. verticillioides (Additional file 9).

These methods can be divided into: 1) univariate linear regression models, proposed to model the associations between individual CN and GE probes [ 280], 2) multivariate linear regression models, integrating statistical power across multiple probes targeting adjacent genes or chromosomal positions [ 281], and 3) nonlinear regression models.

The DOOR method [ 18] uses a data-mining classifier trained on E. coli and Bacillus subtilis, including the intergenic distance, neighborhood conservation across multiple genomes, phylogenetic distance between adjacent genes, information from short DNA motifs, similarity score between GO terms of gene pairs and the length ratio between a pair of genes.

Several features of the adjacent gene pairs, such as the intergenic distance, the conservation of gene pairs across multiple genomes, the functional similarity between adjacent genes, the involvement of a given gene pair in the same biological pathway or physical complex (e.g., protein-protein interaction), gene expression correlations and some other features are used in the classification.

Based on the operon organization table, 694 hypothetical genes with unknown function were categorized into multiple-gene operons with validated co-expression with adjacent genes (Additional file 3).

Multiple lines of evidence suggest that the neurotoxin and adjacent genes evolved from an ancestral collagenase-like gene cluster, linking CNTs to another major family of clostridial proteolytic toxins.